The autotransporter secretion system
نویسندگان
چکیده
منابع مشابه
Identification of secretion determinants of the Bordetella pertussis BrkA autotransporter.
The autotransporters comprise a functionally diverse family of gram-negative proteins that mediate their own export across the bacterial outer membrane. They consist of an amino-terminal passenger region called the "alpha-domain" and the structural hallmark of the autotransporter family, a carboxy-terminal transporter region usually referred to as the "beta-domain." The passenger region can be ...
متن کاملType V protein secretion pathway: the autotransporter story.
Gram-negative bacteria possess an outer membrane layer which constrains uptake and secretion of solutes and polypeptides. To overcome this barrier, bacteria have developed several systems for protein secretion. The type V secretion pathway encompasses the autotransporter proteins, the two-partner secretion system, and the recently described type Vc or AT-2 family of proteins. Since its discover...
متن کاملLimited tolerance towards folded elements during secretion of the autotransporter Hbp.
Many virulence factors secreted by pathogenic Gram-negative bacteria belong to the autotransporter (AT) family. ATs consist of a passenger domain, which is the actual secreted moiety, and a beta-domain that facilitates the transfer of the passenger domain across the outer membrane. Here, we analysed folding and translocation of the AT passenger, using Escherichia coli haemoglobin protease (Hbp)...
متن کاملMechanistic link between β barrel assembly and the initiation of autotransporter secretion.
Autotransporters are bacterial virulence factors that contain an N-terminal extracellular ("passenger") domain and a C-terminal β barrel ("β") domain that anchors the protein to the outer membrane. The β domain is required for passenger domain secretion, but its exact role in autotransporter biogenesis is unclear. Here we describe insights into the function of the β domain that emerged from an ...
متن کاملPertactin beta-helix folding mechanism suggests common themes for the secretion and folding of autotransporter proteins.
Many virulence factors secreted from pathogenic Gram-negative bacteria are autotransporter proteins. The final step of autotransporter secretion is C --> N-terminal threading of the passenger domain through the outer membrane (OM), mediated by a cotranslated C-terminal porin domain. The native structure is formed only after this final secretion step, which requires neither ATP nor a proton grad...
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ژورنال
عنوان ژورنال: Research in Microbiology
سال: 2004
ISSN: 0923-2508
DOI: 10.1016/j.resmic.2003.10.002